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KMID : 0356920110610060493
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Korean Journal of Anesthesiology
2011 Volume.61 No. 6 p.493 ~ p.498
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Insulin effect on bupivacaine-induced cardiotoxicity in rabbits
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Choi Yun-Suk
Lee Kook-Hyun
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Abstract
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Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractory to conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-induced cardiovascular collapse in pentobarbital-anesthetized rabbits.
Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolus of regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulin group (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).
Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10 minutes after the BIE in the insulin group.
Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection, probably through facilitation of cardiac conduction and contraction.
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KEYWORD
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Bupivacaine, Cardiac arrhythmia, Insulin
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